Date(s) - 04/03/2018
4:00 pm - 5:00 pm
Professor of Bioengineering
Professor of Chemical and Biomolecular Engineering
University of Pennsylvania
Dr. Radhakrishnan is a trained Chemical and Biological Engineer who obtained his Bachelor’s Degree from the Indian Institute of Technology in Madras, India, and his Doctoral Degree from Cornell University in Ithaca NY. After Postdoctoral training at the Massachusetts Institute of Technology and at the New York University, her joined the faculty of the University of Pennsylvania, where currently holds the title of Professor of Bioengineering and Professor of Chemical and Biomolecular Engineering. He is also a member of the graduate groups of Genomics and Computational Biology and Biochemistry and Molecular Biology. He is a founding member and the Interim Director of the Penn Institute of Computational Sciences and a member of the NCI funded Penn Physical Sciences in Oncology Center.
Radhakrishnan directs a computational research laboratory with research interests at the interface of biophysics, chemical physics and biomedical engineering. The goal of his computational molecular systems biology laboratory is to provide quantitative and mechanistic molecular and cellular level characterization of complex systems and formulate quantitatively accurate and predictive models in physiology and pathology for systems pharmacology and insilico oncology applications. His lab specializes in several computational algorithms ranging from techniques to treat electronic structure, molecular dynamics, Monte Carlo simulations, and hydrodynamics of complex fluids, in conjunction with the theoretical formalisms of statistical mechanics, and applications of high performance computing in parallel architectures. Current research themes include computational structural biology and systems biology, cell membrane mediated trafficking, targeted drug delivery, and cancer signaling. He has successful and funded collaborations with pharmacologists, cell biologists, biophysical chemists, anesthesiologists, and oncologists primarily through grants from US National Science Foundation, US National Institutes of Health, and the European Commission. Radhakrishnan has authored over 125 articles in leading peer reviewed Journals, serves as a referee for over 45 leading journals, publishers, and federal funding agencies, and serve on the editorial board of five journals. He is a Fellow of the American Institute of Medical and Biological Engineers and serves as the Working Group Leader for High Performance Computing for an Inter-Governmental Panel involving NIH, NSF, NASA, DOE, DOD, and DARPA.
“Using Statistical Mechanics to Build Predictive Models in Bioengineering and Cell Biology”
The talk will focus on the philosophy of using equilibrium and non-equilibrium statistical mechanics as bases to build simulation techniques for building predictive models in cell biology and bioengineering, and collaboratively validating such models in in vitro physical science-based experiments, in vivo in cell culture, and in vivo in organisms (such as mouse). The first theme will embrace the idea of “unit operations” in cell biology to decipher transport mechanisms for intracellular traffic involving cell membrane curvature generation and sensing. The second theme the construction of biophysically based process modeling in quantitative systems pharmacology and insilico oncology). Here, the goal is to understand drug sensitivity and resistance, building cellular models for personalized pharmacokinetics, and in designing nanomaterials for delivering therapeutics using multiscale modeling frameworks. These works are funded by US NIH, NSF, and EU VPH institutes.