Systems and Synthetic Biology and Metabolic Engineering
The research seeks to understand and harness complex cellular systems for industrial biocatalysis and disease prevention through development and application of omics, synthetic biology, metabolic flux engineering, systems biology, and metabolic engineering tools. Research topics include development of Modular Cell Design (MODCELL) technology for rapid creation of novel biocatalysts (Trinh), understanding of mechanisms of cellular robustness against environmental perturbation, development of effective defensive tools to boost cellular robustness for applications from disease prevention to novel biocatalysis (Trinh), and application of computational methods to understand stochastic and spatial effects in cell signaling networks (Abel).
Cong Trinh Takes Aim at Diseases
Ferguson Fellow and Associate Professor Cong Trinh is developing a method to improve the time involved in both identification and removal of pathogens through the concept of a Virulent Pathogen Resistance program, or ViPaRe.
Faculty Feature: Steven Abel
Associate Professor Steven Abel’s research group uses theoretical and computational methods to understand how biological cells interact with their environment.
- Proteome reallocation enables the selective de novo biosynthesis of non-linear, branched-chain acetate esters
- Gene Coexpression Connectivity Predicts Gene Targets Underlying High Ionic-Liquid Tolerance in Yarrowia lipolytica
- Exploring Proteomes of Robust Yarrowia lipolytica Isolates Cultivated in Biomass Hydrolysate Reveals Key Processes Impacting Mixed Sugar Utilization, Lipid Accumulation, and Degradation
- Engineering promiscuity of chloramphenicol acetyltransferase for microbial designer ester biosynthesis