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Engineering promiscuity of chloramphenicol acetyltransferase for microbial designer ester biosynthesis

Trinh's diagram showing the process of changing a single amino acid in alcohol acetyltransferases.

By discovering and simply twisting a single amino acid in alcohol acetyltransferases, Associate Professor Cong Trinh’s team presents an innovative strategy to reprogram microorganisms to make a large array of designer bioesters with broad utility as flavors, fragrances, solvents, and fuels from renewable and sustainable biomass feedstocks in various microorganisms.

This research is published by Metabolic Engineering.